Direct measurement of protein energy landscape roughness

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Direct measurement of protein energy landscape roughness.

The energy landscape of proteins is thought to have an intricate, corrugated structure. Such roughness should have important consequences on the folding and binding kinetics of proteins, as well as on their equilibrium fluctuations. So far, no direct measurement of protein energy landscape roughness has been made. Here, we combined a recent theory with single-molecule dynamic force spectroscopy...

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2005

ISSN: 1469-221X,1469-3178

DOI: 10.1038/sj.embor.7400403